Endocrine Abstracts

The quantification of TSH from a serum or plasma sample constitutes the cornerstone of assessing the thyroid axis in the clinical routine. In addition, T4 and/or T3 levels may be determined to diagnose pathological conditions. However, these data do not necessarily reflect the local action of thyroid hormone in the target tissues and are sensitive to distortion, as best known from pregnancy when chorionic gonadotropin disturbs the regular feedback control. Recently, we identif...

Introduction: Diabetes mellitus (DM) is a complex chronic metabolic disease characterized by elevated blood glucose levels due to insulin resistance and the failure of pancreatic beta cells to compensate. T2D and its complications have reached epidemic proportions worldwide over the past four decades [1]. A very rare condition known as Type B Insulin Resistance (TBIR) is characterized by severe insulin resistance and the presence of circulating autoantibodies (autoAb) directed...

Objective: The aim of this study was to investigate sex-specific associations of two established serum selenium biomarkers, i.e. total selenium and selenoprotein P with type 2 diabetes mellitus (T2D) and hypertension in a large cohort of older people.Methods: 1500 participants with available selenium measurements from the Berlin Aging Study II (BASE-II) were included in this study. In the serum samples, spectroscopy was used to quantify total selenium, a...

Introduction: The thyroid hormone (TH) status is routinely assessed by thyrotropin (TSH) and thyroxine (T4). Both biomarkers are mainly regulated by thyroid hormone receptor beta, whereas many peripheral organs employ the alpha receptor. Serum CD5L is a liver-derived protein under control of both TH receptor isoforms, but the data base is small [1]. An additional biomarker of TH status is needed in particular during pregnancy, where the routine biomarkers become dynamically di...

Introduction: Pregnancy is a challenging time to maintain proper thyroid function in mothers and to provide sufficient thyroid hormones to the developing fetus. Micronutrient deficiencies are very frequent during gestation. So far only a few microelements are recommended as a routine supplementation and there is a gap in understanding the mutual relationship between multiple trace elements. The study aimed to verify the micronutrient status concerning thyroid parameters in the...